CIAT with simultaneous epimerization at two stereocenters. Synthesis of substituted β-methyl-α-homophenylalanines
Identifieur interne : 000F37 ( Main/Exploration ); précédent : 000F36; suivant : 000F38CIAT with simultaneous epimerization at two stereocenters. Synthesis of substituted β-methyl-α-homophenylalanines
Auteurs : Dušan Berkeš [Slovaquie] ; Pavol Jakubec [Slovaquie] ; Dagmar Winklerová [Slovaquie] ; František Považanec [Slovaquie] ; Adam Daich [France]Source :
- Organic & Biomolecular Chemistry [ 1477-0520 ] ; 2007.
Abstract
Diastereoselective aza-Michael additions of phenylethylamine to 3-aroylbutenoic acids are reported. During these processes, efficient control over two new stereogenic centers on the Michael acceptor has been possible via crystallization-induced asymmetric transformation (CIAT). As an application, a convenient two-step synthesis of anti-β-methylhomophenylalanines is also described.
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DOI: 10.1039/b613103d
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Biomol. Chem.</title><idno type="ISSN">1477-0520</idno><idno type="eISSN">1477-0539</idno><imprint><publisher>The Royal Society of Chemistry.</publisher><date type="published" when="2007">2007</date><biblScope unit="volume">5</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="121">121</biblScope><biblScope unit="page" to="124">124</biblScope></imprint><idno type="ISSN">1477-0520</idno></series><idno type="istex">3FCEC6CC540C24DD2071579F239BCFE2C2D79CD2</idno><idno type="DOI">10.1039/b613103d</idno><idno type="ms-id">b613103d</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1477-0520</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Diastereoselective aza-Michael additions of phenylethylamine to 3-aroylbutenoic acids are reported. During these processes, efficient control over two new stereogenic centers on the Michael acceptor has been possible via crystallization-induced asymmetric transformation (CIAT). As an application, a convenient two-step synthesis of anti-β-methylhomophenylalanines is also described.</div></front></TEI><affiliations><list><country><li>France</li><li>Slovaquie</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Le Havre</li></settlement><orgName><li>Université du Havre</li></orgName></list><tree><country name="Slovaquie"><noRegion><name sortKey="Berkes, Dusan" sort="Berkes, Dusan" uniqKey="Berkes D" first="Dušan" last="Berkeš">Dušan Berkeš</name></noRegion><name sortKey="Berkes, Dusan" sort="Berkes, Dusan" uniqKey="Berkes D" first="Dušan" last="Berkeš">Dušan Berkeš</name><name sortKey="Jakubec, Pavol" sort="Jakubec, Pavol" uniqKey="Jakubec P" first="Pavol" last="Jakubec">Pavol Jakubec</name><name sortKey="Jakubec, Pavol" sort="Jakubec, Pavol" uniqKey="Jakubec P" first="Pavol" last="Jakubec">Pavol Jakubec</name><name sortKey="Povazanec, Frantisek" sort="Povazanec, Frantisek" uniqKey="Povazanec F" first="František" last="Považanec">František Považanec</name><name sortKey="Povazanec, Frantisek" sort="Povazanec, Frantisek" uniqKey="Povazanec F" first="František" last="Považanec">František Považanec</name><name sortKey="Winklerova, Dagmar" sort="Winklerova, Dagmar" uniqKey="Winklerova D" first="Dagmar" last="Winklerová">Dagmar Winklerová</name><name sortKey="Winklerova, Dagmar" sort="Winklerova, Dagmar" uniqKey="Winklerova D" first="Dagmar" last="Winklerová">Dagmar Winklerová</name></country><country name="France"><region name="Région Normandie"><name sortKey="Daich, Adam" sort="Daich, Adam" uniqKey="Daich A" first="Adam" last="Daich">Adam Daich</name></region><name sortKey="Daich, Adam" sort="Daich, Adam" uniqKey="Daich A" first="Adam" last="Daich">Adam Daich</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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